North Carolina Central University


Dr. Li-An Yeh

Dr. Li-An YehLi-An Yeh, Ph.D.
Director, Professor of Pharmaceutical Sciences

  • Earned B.S.  in Agricultural Chemistry at National Taiwan University, M.S. in Chemistry at Kent State and Ph.D in Biochemistry at Purdue University
  • Completed Post-Doctoral Fellowship, focused on Membrane Transport/Cell Differentiation, at Harvard University
  • Spent 20 years in industry leading research and leads/drug discovery efforts for companies including Eli Lilly and Company, PerkinElmer Life Sciences, Phytera, OsteoArthritis Sciences, Inc. and Pfizer
  • Contact:  lyeh@nccu.edu or 919-530-7013 

Neuroprotective Agents
Systematic discovery of molecules which enhance the NGF-like growth factors and the elucidation of molecular mechanism for the signal amplification of these molecules will further aid to the therapeutic intervention of neurodegeneration, such as AD, Parkinson’s disease, ALS and Huntington’s disease.

Role of Tau in Alzheimer’s Disease
The elucidation and the kinetics and mechanism of Tau phosphorylation leading to aggregation and binding to microtubules will further shed some light in the role of Tau in Alzheimer’s disease and other neurodegenerative diseases.

PUBLICATIONS:

2012
2011
2010
2009
2008
Nakamura, K, Zawistowski JS, Hughes MA, Sexton JZ, Yeh L-A, Johnson GL, Scott JE.  2008.  Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization.. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 13(5):396-405. Abstract
2004