Li-An Yeh, Ph.D.
Director, Professor of Pharmaceutical Sciences
- Earned B.S. in Agricultural Chemistry at National Taiwan University, M.S. in Chemistry at Kent State and Ph.D in Biochemistry at Purdue University
- Completed Post-Doctoral Fellowship, focused on Membrane Transport/Cell Differentiation, at Harvard University
- Spent 20 years in industry leading research and leads/drug discovery efforts for companies including Eli Lilly and Company, PerkinElmer Life Sciences, Phytera, OsteoArthritis Sciences, Inc. and Pfizer
- Contact: lyeh@nccu.edu or 919-530-7013
Neuroprotective Agents
Systematic discovery of molecules which enhance the NGF-like growth factors and the elucidation of molecular mechanism for the signal amplification of these molecules will further aid to the therapeutic intervention of neurodegeneration, such as AD, Parkinson’s disease, ALS and Huntington’s disease.
Role of Tau in Alzheimer’s Disease
The elucidation and the kinetics and mechanism of Tau phosphorylation leading to aggregation and binding to microtubules will further shed some light in the role of Tau in Alzheimer’s disease and other neurodegenerative diseases.
PUBLICATIONS:
2012
2011
2010
Wallace, BD, Wang H, Lane KT, Scott JE, Orans J, Koo J S, Venkatesh M, Jobin C, Yeh L-A, Mani S et al..
2010.
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.. Science (New York, N.Y.). 330(6005):831-5.
Abstract
2009
2008
2004
Sussman, A, Huss K, Chio L-C, Heidler S, Shaw M, Ma D, Zhu G, Campbell RM, Park T-S, Kulanthaivel P et al..
2004.
Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening.. Eukaryotic cell. 3(4):932-43.
Abstract