North Carolina Central University

Jonathan Z. Sexton, Ph.D.

Jonathan Z. Sexton, Ph.D.
Associate Professor

  • Earned B.S. and Ph.D., both in Chemistry, at the University of California
  • Worked as a Postdoctoral Fellow for the American Cancer Society at Stanford University
  • Spent five years as the owner of Internet Consulting Services developing PHP/MySQL web applications and creating IT infrastructure
  • Contact: or 919-530-6251

Real Time Process Monitoring and Control
This research focuses on implementation of real-time testing and adjustment in biomanufacturing process based on the complete understanding of how the components and related processes impact the final product.  The goal of this research is to develop new tools and data analysis algorithms to improve the quality of batches, reduce production cycle time and facilitate continuous improvement.

Using Nanoparticle-Bio Conjugates to Increase Effective Dose Rates
The goal of this project is to increase the shelf-life, stability, syringability and effective dose rates of monoclonal antibodies (MAbs) using nanoparticle-antibody conjugates. During this process we will investigate nanoparticle-bioconjugates as a drug delivery system.

Treatments for Type-II Diabetes, Metabolic Syndrome and Cardiovascular Diseases
T2D, metabolic syndrome, cardiovascular disease (CVD) and obesity are increasingly prevalent with nearly one in eight federal healthcare dollars spent on diabetes related care alone.  Many symptoms of metabolic syndrome, CVD, and diabetes are shared; however, the molecular mechanisms linking these conditions is unclear. This research seeks to identify molecular probes to further understanding of these diseases.


***ATTENTION:  Applications are invited for a postdoctoral fellowship to perform high-content screening.  Candidates should possess a Ph.D. and/or M.D. degree, and a strong background in cell biology, molecular biology and biochemistry  



Sexton, JZ, Williams KP.  2012.  Evaluating the Peroxisomal Phenotype in High-Content Toxicity Profiling. High-Throughput Screening Methods in Toxicity Testing.
Sexton, JZ, He Q, Forsberg LJ, Brenman JE.  2010.  High content screening for non-classical peroxisome proliferators.. International journal of high throughput screening. 2010(1):127-140. Abstract
Sexton, JZ, He QP, LJ F, Brenman JE.  2010.  High content screening for nonclassical peroxisome proliferators. International Journal of High Throughput Screening. 2010(1)
Nakamura, K, Zawistowski JS, Hughes MA, Sexton JZ, Yeh L-A, Johnson GL, Scott JE.  2008.  Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization.. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 13(5):396-405. Abstract