Carla Edge Oldham, Ph.D.
Carla Edge Oldham, Ph.D.
Assistant Research Professor
- Earned B.S. in Chemistry at Hampton University in VA and Ph.D. in Biochemistry and Molecular Biology at Purdue University
- Spent two years as a Postdoctoral Fellow at NIEHS/NIH – discovered in vivo ubiquitination of the endocytic adaptor protein Epsin and mapped the area of ubiquitination
- Contact: coldham@nccu.edu or 919-572-0244
Investigation of the Role of CHK in Neuronal Development
This project explores the role of Csk Homologous Kinase (CHK) in neurite outgrowth and signaling pathways as well as the translocation of CHK. The overall goal is to elucidate the role(s) of CHK in neuronal cell signaling in order to
1) develop a HTS screening assay to detect the absence or presence of CHK in tumor cells and
2) find small molecules that can inhibit or induce the expression of CHK.
PUBLICATIONS:
.
2011. A trifluoromethyl analog of verbenachalcone promotes neurite outgrowth and cell proliferation of NeuroScreen-1 cells.. Cellular and molecular neurobiology. 31(1):145-53. Abstract
.
2002. The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination.. Current biology : CB. 12(13):1112-6. Abstract
.
2001. Mitogenesis and endocytosis: What's at the INTERSECTIoN? Oncogene. 20(44):6300-8. Abstract