Andy Li, M.D., Ph.D
Professor of Pharmaceutical Sciences
Mechanism and Treatment of Brain Damage After Cerebral Stroke
The core focus of this research is cell death and survival pathways, free radicals, neuro-inflammation, astrocytic response and neuro-protection after stroke. The study seeks to determine validity of the hypothesis that cerebral stroke leads to neuron damage by increasing free radical production, enhancing neuro-inflammation, suppressing cell survival pathways and causing cell death of necrosis and/or apoptosis. It is believed that agents aimed at blocking these biochemical cascades could provide protection against stroke.
Exacerbation Effects of Diabetes and Hyperglycemia on Stroke
Core focus revolves around mechanisms by which hyperglycemia mellitus enhances ischemic brain damage. The research seeks to prove that 1) hyperglycemia enhances ischemic brain damage by causing early mitochondrial failure and 2) preservation of mitochondrial function reduces hyperglycemia enhanced damage.