North Carolina Central University


Andy Li, M.D., Ph.D

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Andy Li, M.D., Ph.D
Professor of Pharmaceutical Sciences

  • Earned B.S. and M.D. in Medicine in China and completed Neuroscience doctoral work at the University of Lund in Sweden
  • Prepared for teaching career as a senior research scientist at Queens Medical Center
  • Taught at University of Hawaii for three years prior to coming to NCCU
  • Awarded a NIH/COBRE grant for 2001-2007, NIH/RCMI grant for 2001-2006 and NIH/RO1 grant for 2007-2012
  • Contact: pli@nccu.edu or 919-530-6872

Mechanism and Treatment of Brain Damage After Cerebral Stroke
The core focus of this research is cell death and survival pathways, free radicals, neuro-inflammation, astrocytic response and neuro-protection after stroke. The study seeks to determine validity of the hypothesis that cerebral stroke leads to neuron damage by increasing free radical production, enhancing neuro-inflammation, suppressing cell survival pathways and causing cell death of necrosis and/or apoptosis. It is believed that agents aimed at blocking these biochemical cascades could provide protection against stroke.

Exacerbation Effects of Diabetes and Hyperglycemia on Stroke
Core focus revolves around mechanisms by which hyperglycemia mellitus enhances ischemic brain damage.  The research seeks to prove that 1) hyperglycemia enhances ischemic brain damage by causing early mitochondrial failure and 2) preservation of mitochondrial function reduces hyperglycemia enhanced damage. 

PUBLICATIONS:

2012
Ahmad, S, Hughes MA, Yeh L-A, Scott JE.  2012.  Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors.. Journal of biomolecular screening. 17(7):957-65. Abstract
2011
Sexton, JZ, Danshina PV, Lamson DR, Hughes M, House AJ, Yeh L-A, O'Brien DA, Williams KP.  2011.  Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS).. Current chemical genomics. 5:30-41. Abstract
Ahmad, S, Hughes MA, Lane KT, Redinbo MR, Yeh L-A, Scott JE.  2011.  A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors.. Current chemical genomics. 5:13-20. Abstract
2010
Lamson, DR, House AJ, Danshina PV, Sexton JZ, Sanyang K, O'Brien DA, Yeh L-A, Williams KP.  2010.  Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells.. Protein expression and purification. Abstract
Wallace, BD, Wang H, Lane KT, Scott JE, Orans J, Koo J S, Venkatesh M, Jobin C, Yeh L-A, Mani S et al..  2010.  Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.. Science (New York, N.Y.). 330(6005):831-5. Abstract
Mendelev, N, Mehta SL, Witherspoon S, He Q, Sexton JZ, Li AP.  2010.  Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance.. Mitochondrion. Abstract
Sexton, JZ, Wigle TJ, He Q, Hughes MA, Smith GR, Singleton SF, Williams AL, Yeh L-A.  2010.  Novel Inhibitors of E. coli RecA ATPase Activity.. Current chemical genomics. 4:34-42. Abstract
2009
Wigle, TJ, Sexton JZ, Gromova AV, Hadimani MB, Hughes MA, Smith GR, Yeh L-A, Singleton SF.  2009.  Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coli.. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 14(9):1092-101. Abstract
2008
Nakamura, K, Zawistowski JS, Hughes MA, Sexton JZ, Yeh L-A, Johnson GL, Scott JE.  2008.  Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization.. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 13(5):396-405. Abstract
2006
Yang, LJ, Li YB.  2006.  Detection of viable Salmonella using microelectrode-based capacitance measurement coupled with immunomagnetic separation. Journal of Microbiological Methods. 64:9-16. Abstract
2004
Sussman, A, Huss K, Chio L-C, Heidler S, Shaw M, Ma D, Zhu G, Campbell RM, Park T-S, Kulanthaivel P et al..  2004.  Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening.. Eukaryotic cell. 3(4):932-43. Abstract
Yang, LJ, Li YB, Erf GF.  2004.  Interdigitated array microelectrode-based electrochemical impedance immunosensor for detection of Escherichia coli O157 : H7. Analytical Chemistry. 76:1107-1113. Abstract
Yang, LJ, Li YB, Griffis CL, Johnson MG.  2004.  Interdigitated microelectrode (IME) impedance sensor for the detection of viable Salmonella typhimurium. Biosensors & Bioelectronics. 19:1139-1147. Abstract
1998
Klose, TS, Ibeanu GC, Ghanayem BI, Pedersen LG, Li L, Hall SD, Goldstein JA.  1998.  Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen.. Archives of biochemistry and biophysics. 357(2):240-8. Abstract
1996
Ibeanu, GC, Ghanayem BI, Linko P, Li L, Pederson LG, Goldstein JA.  1996.  Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.. The Journal of biological chemistry. 271(21):12496-501. Abstract